Profhilo, Sculptra, hyperdiluted Radiesse, and Rejuran at Cosmolaser Medical Centre in Sharjah. Unlike fillers, biostimulators work by triggering your skin’s own collagen and elastin production.
So the improvement is genuine, gradual, and deeply natural. Firmer skin. Better texture. Real results built by your own biology.
Most people know what fillers do they add volume to a specific area. Biostimulators work on an entirely different principle. Rather than adding a substance to replace lost volume, they introduce a signal to the skin triggering the body’s own fibroblast cells to produce new collagen and elastin. The improvement that follows is not created by the product. It is created by your own skin.
This distinction matters for three reasons. First, the results look genuinely natural because they are built from your own tissue. Second, the improvement continues for weeks or months after the injections are complete, as the collagen-production process takes time to develop. Third, the improvement addresses skin quality, texture, firmness, elasticity, hydration rather than simply replacing lost volume or freezing movement.
Biostimulators are not a replacement for fillers or Botox. They are a different tool that addresses a different problem: the progressive decline in the quality and density of your skin’s collagen scaffolding that begins in your late twenties and accelerates significantly after forty. For patients who notice that their skin looks dull, thin, loose, or crepey rather than (or in addition to) looking volumetrically deflated biostimulators are typically the right first-line treatment.
Our Acne Control Treatment is a comprehensive skincare service designed to effectively target and manage all types of acne, including blackheads, whiteheads, papules, pustules, and cystic breakouts.
This treatment is suitable for both teenagers and adults experiencing mild to severe acne, as well as those dealing with post-acne marks or scarring. Our approach combines deep cleansing, exfoliation, and targeted therapy to reduce inflammation, unclog pores, and promote clearer, healthier skin.
The session begins with a personalized skin analysis conducted by our licensed skincare professionals to understand the root causes of your acne. This is followed by a gentle, yet thorough cleansing process to remove excess oil, dirt, and impurities.
Depending on your skin’s condition, a combination of exfoliating acids (such as salicylic acid or glycolic acid), extractions, and anti-bacterial treatments will be applied to minimize active breakouts and prevent new ones from forming. A soothing mask is then used to calm irritation and balance the skin.
To enhance results, we offer add-ons such as LED light therapy to kill acne-causing bacteria and accelerate healing. Our Acne Control Treatment also includes aftercare guidance and product recommendations tailored to your skin type and concerns.
With consistent sessions and proper at-home care, clients typically see significant improvement in skin texture, tone, and overall clarity. This service is ideal for those seeking a professional, long-term solution to acne-prone skin.
Profhilo is the most widely requested biostimulator in the UAE and the UK — and the most appropriate starting point for patients new to this category. Unlike conventional fillers, Profhilo contains a very high concentration of pure, uncrosslinked hyaluronic acid that does not sit in one place. It diffuses through the tissue, deeply hydrating it while simultaneously triggering fibroblasts to produce both collagen and elastin.
The result is a genuine improvement in skin quality — not added volume, not frozen movement, not a structural change. Patients describe their skin as feeling and looking ‘like it did ten years ago’: firmer, more elastic, more hydrated, with a natural inner glow that no topical product replicates.
Profhilo is particularly effective for:
Detail | Standard Protocol | Maintenance |
|---|---|---|
Sessions | 2 sessions, 4 weeks apart | Top-up session every 6 months |
Injection points | 5 BAP points per side (face) — standardised technique | Same protocol |
Areas | Face · Neck · Décolletage · Hands | Any of the above |
Onset | Skin quality improvement within 2–3 weeks of session 1 | Progressive with each top-up |
Full effect | 8 weeks after session 2 | Maintained with 6-monthly top-ups |
Duration | Up to 6 months per course | Results compound with regular treatment |
Reversibility | HA-based — fully reversible | — |
Sculptra is the original FDA-approved collagen biostimulator — in clinical use for over two decades, initially for HIV-related facial lipoatrophy before being adopted widely in aesthetic medicine. It contains poly-L-lactic acid (PLLA) microparticles that act as a deep-tissue scaffold signal: they prompt fibroblasts to produce high-quality structural collagen over a period of months.
Unlike Profhilo — which improves skin quality — Sculptra also restores significant volume over time. As the collagen builds, the face regains the three-dimensional fullness and structural support that disappears with age. The results are gradual and completely natural-looking, precisely because they are built from the patient’s own collagen — not added from outside.
Sculptra is appropriate for patients with:
Detail | Standard Protocol | Maintenance |
|---|---|---|
Sessions | 3–4 sessions, 4–6 weeks apart | Touch-up vial every 12–24 months |
Onset | Gradual — first visible improvement at 6–8 weeks | Results build progressively |
Full effect | 3–6 months after final session | Peak result maintained for 18–24 months |
Areas | Up to 2 years | One of the longest-lasting aesthetic injectables available |
Reversibility | Cheeks · Temples · Nasolabial folds · Lower face · Jawline · Body | — |
Reversibility | NOT reversible — naturally metabolised | Patient selection and conservative dosing essential |
Radiesse is calcium hydroxylapatite (CaHA) — a mineral compound found naturally in the body, also used in bone and dental applications. In its standard concentration, it acts as a structural filler with immediate volumising effect. When diluted with saline to approximately half its standard concentration — ‘hyperdiluted Radiesse’ — it loses its volumising effect and transforms into a pure biostimulator: the CaHA microspheres act as a scaffold that triggers significant new collagen and elastin production.
Hyperdiluted Radiesse is particularly valuable for two applications that other biostimulators do not address as effectively: skin tightening on the neck and lower face where skin laxity is significant, and skin quality improvement on body areas — décolletage, inner arms, abdomen, and knees — where the skin has become thin and lax.
Detail | Standard Protocol | Notes |
|---|---|---|
Sessions | 1–2 sessions, 4–6 weeks apart | Body areas may require more sessions |
Onset | Initial improvement at 4–6 weeks | Collagen synthesis peaks at 3 months |
Full effect | 3 months after treatment | — |
Duration | 12–18 months | — |
Areas | Neck · Lower face · Décolletage · Inner arms · Abdomen · Inner thighs | — |
Reversibility | NOT reversible — naturally metabolised | — |
Rejuran (also known as PDRN therapy) uses polynucleotides — fragments of salmon DNA that are biochemically compatible with human tissue — to stimulate skin repair and regeneration at a cellular level. It works differently to all other biostimulators: rather than triggering fibroblast collagen production via a scaffold signal, polynucleotides activate growth factor receptors directly, stimulating tissue repair and new cell formation.
Rejuran excels in situations where the skin has been damaged rather than simply aged: acne scarring, post-inflammatory hyperpigmentation, sun damage, and generalised skin thinning from UV exposure — all common concerns in the UAE climate. It also produces a distinctive improvement in skin texture and radiance that patients describe as their skin ‘healing itself.’
Detail | Standard Protocol | Notes |
|---|---|---|
Sessions | 3–4 sessions, 2–4 weeks apart | Closer intervals for more damaged skin |
Onset | Skin quality improvement within 2–3 weeks of first session | — |
Full effect | 6–8 weeks after final session | — |
Duration | 6–12 months | — |
Areas | Face · Neck · Under-eye | Particularly effective under-eye for thin skin |
Reversibility | HA carrier is reversible; PN component metabolised naturally | — |
The right biostimulator depends on your primary skin concern, the areas you want to treat, your timeline for results, and your tolerance for gradual versus immediate change. Use this guide as a starting point — your physician will recommend the optimal treatment or combination at consultation.
| Primary Concern | Profhilo | Sculptra | Radiesse (HD) | Rejuran |
|---|---|---|---|---|
| Skin Concerns | ||||
| Skin dehydration & dullness | Excellent | |||
| Fine lines from skin thinning | Excellent | Excellent | ||
| Skin laxity — early/moderate | Excellent | Excellent | ||
| Significant volume loss | Excellent | |||
| Body & Treatment Areas | ||||
| Neck & décolletage laxity | Excellent | |||
| Sun-damaged / thinned skin | Excellent | |||
| Post-acne skin repair | Excellent | |||
| Body skin tightening | Excellent | |||
| Treatment Profile | ||||
| Preventative (late 20s–30s) | Ideal | |||
| Reversibility | Reversible | |||
| Time to full result | ||||
Protocol | Treatments Combined
| Best For |
|---|---|---|
Skin Quality Foundation | Profhilo × 2 courses (4 sessions total, 6 months apart) | First-time biostimulator patients — skin hydration, elasticity, and glow |
Deep Restoration | Sculptra × 3 sessions + Profhilo × 2 sessions | Patients with both volume loss and skin quality decline (typically 40s–50s) |
Neck & Décolletage Tightening | Hyperdiluted Radiesse × 2 + Profhilo neck × 2 | Lax neck skin, horizontal neck lines, crepey décolletage |
Post-Laser Skin Recovery | Rejuran × 3 sessions starting 4 weeks after CO2 or RFMN laser | Accelerates skin healing, builds new collagen alongside laser-induced remodelling |
Complete Anti-Ageing Injectable Suite | Botox + Fillers (volume) + Sculptra (collagen) + Profhilo (quality) | Comprehensive facial rejuvenation addressing dynamic lines, volume, structure, and skin quality |
Sun Damage Repair (UAE-Specific) | Rejuran × 4 + Profhilo × 2 + optional Pico laser or chemical peel | Sun-damaged, hyperpigmented, or thickened/thinned skin from UAE climate |
All combination protocols are assessed and planned individually at your consultation. Product sequencing, session spacing, and the order of treatments relative to other procedures (laser, microneedling, Botox) are all relevant to achieving the best outcome and will be mapped at your first appointment.
Profhilo, 2-session course. Facial skin laxity and dullness. Result photographed at 8 weeks post session 2. Patient described result as ‘skin looks 5 years younger — but naturally.’ Female, 44, Sharjah.
Facial and skin quality analysis. Your physician assesses your skin's current condition — firmness, texture, hydration, volume, and laxity — and recommends the most appropriate biostimulator, dosing protocol, and treatment sequence for your goals and anatomy.
Avoid blood-thinning supplements (fish oil, vitamin E, aspirin, ibuprofen) and alcohol for 48 hours before treatment. Arrive with a clean face. Topical numbing cream is applied 20–30 minutes before injection.
The biostimulator is injected using the technique appropriate to the product — Profhilo uses 5 standardised BAP points per side; Sculptra uses a fanning technique at the deep tissue plane; hyperdiluted Radiesse uses a cannula for broader coverage; Rejuran uses micro-injections at a superficial plane. Products are not interchangeable in technique.
Expect mild swelling and occasional pinpoint bruising at injection sites, resolving within 24–72 hours. For Sculptra and Radiesse, gentle massage of the treated area as instructed is essential — your physician will demonstrate the technique before you leave.
Biostimulators are not assessed at 2 weeks — results take 6–12 weeks to develop. Your next session is scheduled at the end of your first appointment, following the recommended protocol spacing.
The most important thing to understand about biostimulators is the timeline. You will not see the result immediately. The collagen production process takes weeks. The patience is rewarded with a result that looks genuinely natural — because it is genuinely natural.
We’ve gathered the most common questions to help you feel informed, confident, and ready for your journey with us.
A filler adds a substance — typically hyaluronic acid — to replace lost volume immediately. You can see and feel the result within days. A biostimulator works differently: it introduces a signal to the skin that triggers your own fibroblast cells to produce new collagen and elastin. The result builds gradually over 6–12 weeks and is built from your own tissue — not added from outside. Fillers address volume. Biostimulators address skin quality, firmness, and collagen density. Both are valuable — they solve different problems, and many patients benefit from both.
Profhilo is not a filler. It contains hyaluronic acid — the same substance used in many fillers — but it works on a completely different principle. Conventional HA fillers are cross-linked (structurally reinforced) to remain in one place and add volume. Profhilo is uncrosslinked, which means it diffuses through the tissue rather than sitting in one location. It does not add volume. Its mechanism is bio-remodelling: it deeply hydrates the tissue and triggers fibroblasts to produce collagen and elastin. The result is improved skin quality — not a structural change.
The standard Profhilo protocol is two sessions spaced four weeks apart. This completes one course of treatment. The full result develops over the 6–8 weeks following the second session. Maintenance sessions — one per course, every 6 months — are recommended to sustain the result. Many patients choose to maintain two courses per year. Because the collagen improvement compounds with each course, regular long-term Profhilo patients often notice that their results become more pronounced over time.
Sculptra results typically last up to two years — making it one of the longest-lasting injectable aesthetic treatments available. The longevity comes from its mechanism: Sculptra stimulates your own collagen production, and that collagen persists even after the PLLA particles have been metabolised by the body. Most patients choose a maintenance vial every 12–24 months after completing their initial 3–4 session protocol. Because each maintenance session adds to the existing collagen foundation, long-term Sculptra patients tend to need less product over time.
Yes — and the combination produces far better results than any single treatment alone. Botox addresses dynamic expression lines. Fillers restore structural volume. Biostimulators improve the quality of the skin itself — its firmness, hydration, texture, and elasticity. These three categories address three different aspects of facial ageing. At Cosmolaser, multi-treatment protocols are standard for patients who want comprehensive rejuvenation. Product sequencing — which treatment to do first and in what order — is important and is mapped at consultation.
Minimal downtime. Expect mild swelling and occasional pinpoint bruising at injection sites, resolving within 24–72 hours. Profhilo patients sometimes notice small bumps at the injection points for 12–24 hours as the product begins to spread — this is normal and resolves without treatment. Sculptra and Radiesse patients are instructed to massage the treated area gently for 5 minutes, five times a day, for five days (the '5-5-5 rule') — this prevents nodule formation and ensures even product distribution. You can return to normal activities immediately after any biostimulator treatment.
Collagen production begins declining at approximately 1–1.5% per year from the mid-twenties. The optimal time to start biostimulator treatment — particularly Profhilo — is before significant skin quality decline is visible, typically in the late twenties to mid-thirties. Earlier treatment is preventative: it maintains the collagen scaffold rather than trying to rebuild it from a significantly depleted baseline. That said, biostimulators are effective at any age — patients in their fifties and sixties achieve meaningful skin quality improvement. The later you start, the more intensive the initial protocol typically needs to be.
All biostimulators used at Cosmolaser are CE-marked, DHA-approved, and have extensive clinical safety profiles. Profhilo and Rejuran are HA-based. Sculptra (PLLA) has been in clinical use for over 20 years. Radiesse (CaHA) is composed of a mineral found naturally in the body. Side effects are mild and temporary — swelling, bruising, and tenderness at injection sites, resolving within 2–5 days. Technique matters significantly for safety outcomes: Sculptra and Radiesse require correct depth, dilution, and post-treatment massage protocol. At Cosmolaser, all biostimulators are physician-administered and all Sculptra/Radiesse patients receive detailed aftercare instructions and a follow-up appointment.